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High concentrations of bioactive glass material (BioGran®) vs. autogenous bone for sinus floor elevation

Identifieur interne : 008489 ( Main/Exploration ); précédent : 008488; suivant : 008490

High concentrations of bioactive glass material (BioGran®) vs. autogenous bone for sinus floor elevation

Auteurs : Ette S. Tadjoedin [Pays-Bas] ; Gert L. De Lange [Pays-Bas] ; D. M. Lyaruu [Pays-Bas] ; Luit Kuiper [Pays-Bas] ; Elisabeth H. Burger [Pays-Bas]

Source :

RBID : ISTEX:A3D414AAA5A24834EB2369019663888048ECB67C

English descriptors

Abstract

Abstract: In this study, high concentrations of bioactive glass (BG) particles were compared with autogenous bone in their capacity to augment maxillary bone when grafted in the human sinus floor using a split mouth design. Three female patients with severe maxillary atrophy underwent bilateral sinus floor elevation and bone grafting using 80–100% BG particles (300–355 μm in size) mixed with 20% to 0% iliac crest bone particles at one (experimental) side, and 100% iliac crest derived bone particles at the other (control) side. A total of 22 bone biopsies was taken at the time of fixture installation; that is, at 4, 6 and 15 months after grafting, and processed for histology and histomorphometry. At the control (autogenous bone) sides, trabecular bone amounted to 39% of the biopsy volume in the graft (site) at 4 months, almost 41% at 6 months, and 42% at 15 months. This bone contained viable osteocytes and was mostly of mature, lamellar type. At the experimental (BG particles) sides, the graft consisted of 27% of mostly woven (and some lamellar) bone at 4 months, 36% (woven and lamellar) bone at 6 months, and 39% (mainly lamellar) bone at 15 months. The grafted BG particles started to excavate at 4 months and their centers gradually filled with bone tissue. As a consequence, the volume of BG particles in the biopsy decreased from 29% at 4 months to 15% at 6 months and 8% at 15 months. The BG particles appeared to resorb within 1–2 years by dissolution rather than by osteoclastic activity. Parameters for bone turnover (% osteoid surface, % resorption surface) indicated that bone remodeling was very active at both experimental and control sides, during more than 6 months. These results suggest that mixtures of mainly (80–90%) BG particles and some (10–20%) autogenous bone are effective for bone regeneration in the augmented sinus offer 6 months healing time, while about 12 months healing time is needed for 100% BG particles.

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DOI: 10.1034/j.1600-0501.2002.130412.x


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Le document en format XML

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<term>Autogenous bone</term>
<term>Autogenous bone particles</term>
<term>Bioactive</term>
<term>Bioactive glass</term>
<term>Bioactive glass material</term>
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<term>Bone volume</term>
<term>Clin</term>
<term>Control side</term>
<term>Dental implants</term>
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<term>High concentration</term>
<term>High concentrations</term>
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<term>Hueso autogeno</term>
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<term>Implant</term>
<term>Implant placement</term>
<term>Implants research</term>
<term>International journal</term>
<term>Knochen</term>
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<term>Lamellar type</term>
<term>Maxilla</term>
<term>Maxillary</term>
<term>Maxillary sinus</term>
<term>Maxillofacial</term>
<term>Maxillofacial implants</term>
<term>Maxillofacial surgery</term>
<term>Meses</term>
<term>Mois</term>
<term>Monaten</term>
<term>Nach</term>
<term>Narrow size range</term>
<term>Oral impl</term>
<term>Osteoid</term>
<term>Osteoid layers</term>
<term>Osteoid surface</term>
<term>Particle</term>
<term>Particules</term>
<term>Preliminary report</term>
<term>Present study</term>
<term>Quatre mois</term>
<term>Resorption</term>
<term>Severe maxillary atrophy</term>
<term>Sinus</term>
<term>Table2</term>
<term>Tadjoedin</term>
<term>Tetracycline</term>
<term>Total bone volume</term>
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<term>Unstained sections</term>
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<div type="abstract">Abstract: In this study, high concentrations of bioactive glass (BG) particles were compared with autogenous bone in their capacity to augment maxillary bone when grafted in the human sinus floor using a split mouth design. Three female patients with severe maxillary atrophy underwent bilateral sinus floor elevation and bone grafting using 80–100% BG particles (300–355 μm in size) mixed with 20% to 0% iliac crest bone particles at one (experimental) side, and 100% iliac crest derived bone particles at the other (control) side. A total of 22 bone biopsies was taken at the time of fixture installation; that is, at 4, 6 and 15 months after grafting, and processed for histology and histomorphometry. At the control (autogenous bone) sides, trabecular bone amounted to 39% of the biopsy volume in the graft (site) at 4 months, almost 41% at 6 months, and 42% at 15 months. This bone contained viable osteocytes and was mostly of mature, lamellar type. At the experimental (BG particles) sides, the graft consisted of 27% of mostly woven (and some lamellar) bone at 4 months, 36% (woven and lamellar) bone at 6 months, and 39% (mainly lamellar) bone at 15 months. The grafted BG particles started to excavate at 4 months and their centers gradually filled with bone tissue. As a consequence, the volume of BG particles in the biopsy decreased from 29% at 4 months to 15% at 6 months and 8% at 15 months. The BG particles appeared to resorb within 1–2 years by dissolution rather than by osteoclastic activity. Parameters for bone turnover (% osteoid surface, % resorption surface) indicated that bone remodeling was very active at both experimental and control sides, during more than 6 months. These results suggest that mixtures of mainly (80–90%) BG particles and some (10–20%) autogenous bone are effective for bone regeneration in the augmented sinus offer 6 months healing time, while about 12 months healing time is needed for 100% BG particles.</div>
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